منابع مشابه
Towards a Pharmacophore for Amyloid
Diagnosing and treating Alzheimer's and other diseases associated with amyloid fibers remains a great challenge despite intensive research. To aid in this effort, we present atomic structures of fiber-forming segments of proteins involved in Alzheimer's disease in complex with small molecule binders, determined by X-ray microcrystallography. The fiber-like complexes consist of pairs of β-sheets...
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Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...
متن کاملSearch for the Pharmacophore of Histone Deacetylase Inhibitors Using Pharmacophore Query and Docking Study
Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...
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Background: The fourth industrial revolution consists of combining network devices with cloud computing methods and analyzing large data and artificial intelligence, which makes it possible to call such an infrastructure smart. In a Smart Hospital, all things and devices are designed to be connected and integrated, thus achieving better patient care, increasing efficiency and reducing time wast...
متن کاملTowards modeling of amyloid fibril structures.
Amyloid fibrils are associated with a number of debilitating diseases, including Alzheimer's disease and variant Creutzfeldt-Jakob disease. The elucidation of the structure of amyloid fibrils is an important step toward understanding the mechanism of amyloid formation and developing therapeutic agents for amyloid diseases. Despite great interests and substantial efforts from various research co...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2011
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001080